Apolipoprotein C3 exacerbates vascular calcification by promoting ferroptosis via the TLR2/AMPK pathway in vascular smooth muscle cells
We demonstrated that ApoC3 exacerbated VC and increased the osteogenic transdifferentiation in VSMCs by increasing ferroptosis. ApoC3 might be a potential target for VC treatment.
Authors
- Qiang Shen (ORCID: https://orcid.org/0000-0002-1491-5434)
- Yitong Xu (ORCID: https://orcid.org/0000-0001-8392-8610)
- Yuan Fang
- Zhao Dong
- Yuhui Wang
- Zihao Zhou
- Ling Zhang
- Xunde Xian
- Lei He
- Lin Yao
- Wei Huang
- Yufei Han
- Changyun Liu
- Kaikai Lu
- Lianxin Zhang
- Chao Zhai
- Huan Wang
- Erdan Dong
- Jinxuan Chen
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Peking University First Hospital (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- Redox Biology
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1016/j.redox.2026.104088
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00