Bacterial and fungal infections in infants born before 24 weeks’ gestation: a review

Infants born before 24 weeks' gestational age face unique challenges compared to more mature preterm infants. This includes a higher risk of infection, which remains a leading cause of morbidity and mortality. Over the last two decades, advancements in neonatal care have resulted in higher rates of survival. However, invasive bacterial and fungal infections continue to pose significant threats. This narrative review highlights the epidemiology, microbiology, and related outcomes of bacterial and fungal infections in infants born before 24 weeks' gestational age. This review also discusses major knowledge gaps in infection epidemiology, prevention, and management, highlighting the need for more robust international data and innovative strategies to address the unique vulnerabilities of these infants.

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Publication Details

Journal
Journal of Perinatology
Published
2026-02-16
DOI
https://doi.org/10.1038/s41372-026-02562-8
Primary Topic
Neonatal and Maternal Infections
Type
article
Field-Weighted Citation Impact
0.00
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article

Bacterial and fungal infections in infants born before 24 weeks’ gestation: a review

Matthew B Green, Dustin D. Flannery, Johan Ågren, Kaashif A. Ahmad et al.
Journal of Perinatology
Neonatal and Maternal Infections
article

Bacterial and fungal infections in infants born before 24 weeks’ gestation: a review

Matthew B Green, Dustin D. Flannery, Johan Ågren, Kaashif A. Ahmad, Matthew A. Rysavy, Satoshi Kusuda, Carl H. Backes, Katrin Mehler, Kourtney Vier, Tarah T Colaizy, Tetsuya Isayama
article en

Abstract

Infants born before 24 weeks' gestational age face unique challenges compared to more mature preterm infants. This includes a higher risk of infection, which remains a leading cause of morbidity and mortality. Over the last two decades, advancements in neonatal care have resulted in higher rates of survival. However, invasive bacterial and fungal infections continue to pose significant threats. This narrative review highlights the epidemiology, microbiology, and related outcomes of bacterial and fungal infections in infants born before 24 weeks' gestational age. This review also discusses major knowledge gaps in infection epidemiology, prevention, and management, highlighting the need for more robust international data and innovative strategies to address the unique vulnerabilities of these infants.

Journal of Perinatology
University of Iowa (US), Nationwide Children's Hospital (US), Children's Hospital of Philadelphia (US), Uppsala University Hospital (SE), Kyorin University (JP), University of Alabama at Birmingham (US), National Center For Child Health and Development (JP), Woman’s Hospital of Texas (US), University Hospital Cologne (DE), Rowan University (US), University of Pennsylvania (US), The University of Texas Health Science Center at Houston (US)
Openalex Percentile: Top 56%
Neonatal and Maternal Infections
DOIOpen Access PDFOpenAlex
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Bacterial and fungal infections in infants born before 24 weeks’ gestation: a review — Matthew B Green, Dustin D. Flannery, et al. · Journal of Perinatology (2026) | TGRS Research Map | TGRS