Synergistic therapeutic effects of metformin and curcumin on polycystic ovary syndrome via regulation of insulin resistance and oxidative stress in a rat model

Combined administration of metformin and curcumin demonstrated synergistic therapeutic effects in PCOS rats by concurrently addressing insulin resistance and oxidative stress. These findings support the clinical potential of this combination as an effective strategy for managing PCOS. Further clinical studies are necessary to validate these promising preclinical findings.