Assessing symptom severity in patients with markedly treatment-resistant depression: Insights from the RECOVER trial
The MADRS, QIDS-C, and QIDS-SR are suitable for use in markedly TRD. Whether sadness, energy, interest, guilt, and concentration are "core" symptoms that are especially sensitive to change deserves further study.
Authors
- Mark T. Bunker (ORCID: https://orcid.org/0000-0001-5871-0687)
- Ying-Chieh Lee (ORCID: https://orcid.org/0000-0002-5414-5497)
- Gustavo Alva (ORCID: https://orcid.org/0000-0001-9742-398X)
- João Quevedo (ORCID: https://orcid.org/0000-0002-1577-3351)
- A. John Rush
- Charles R. Conway
- Harold A. Sackeim
- Thomas Carmody
- Scott T. Aaronson
Institutions
- Medical University of South Carolina (US)
- Washington University in St. Louis (US)
- Sheppard Pratt Health System (US)
- Duke-NUS Medical School (SG)
- LivaNova (United Kingdom) (GB)
- ATP Clinical Research (United States) (US)
- The University of Texas Health Science Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1016/j.jad.2026.121447
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00