miRNA expression profile as a potential tool for discrimination between bacterial and interstitial cystitis

Our results show that miRNA expression and its RA-validated targets, and enriched signaling pathways, differ between the two types of cystitis and might depend on the type of bladder inflammation. The mouse model of IC has some similarities with human IC, confirming that it is a useful tool to identify novel potentially discriminatory biomarkers between BC and IC, such as <i>miR-301a-3p</i>, and also potential therapeutic targets for IC (e.g., <i>NKRF</i> and NF-κB).