Photodynamic therapy with ring-fused chlorins: a vision-preserving approach for retinoblastoma
Overall, the research confirmed that Px1-based photodynamic therapy has cytotoxic potential against Retinoblastoma, highlighting its promise as a treatment option for Retinoblastoma lesions while maintaining retinal integrity and function. Future studies should explore repeated or combination treatments to enhance tumour control in advanced disease, thereby accelerating the potential clinical translation of this approach for childhood Retinoblastoma.
Authors
- Raquel Boia (ORCID: https://orcid.org/0000-0002-0479-3066)
- Beatriz Serambeque (ORCID: https://orcid.org/0000-0002-3634-859X)
- Ana Cristina Gonçalves (ORCID: https://orcid.org/0000-0003-1470-4802)
- M. Pineiro
- M. Laranjo
- Gonçalo Brites
- Maria Filomena Botelho (ORCID: https://orcid.org/0000-0001-7202-1650)
- Bruna D. P. Costa (ORCID: https://orcid.org/0000-0002-3995-0164)
- António Francisco Ambrósio (ORCID: https://orcid.org/0000-0002-0477-1641)
- Tarcísio Guerra Guimarães (ORCID: https://orcid.org/0000-0003-4547-3891)
- Rui B. Proença
- R.S. Alves
- Catarina Mestre (ORCID: https://orcid.org/0000-0003-4884-1039)
- Ricardo Jorge Teixo
- Joana Margarido
- Filipa I. Baptista
- Teresa M. V. D. Pinho e Melo
- Denise Moreno
Institutions
- University of Évora (PT)
- Association for Innovation and Biomedical Research on Light and Image (PT)
- Instituto Português de Oncologia de Coimbra Francisco Gentil (PT)
- Instituto de Investigação Científica Tropical (PT)
- University of Coimbra (PT)
Publication Details
- Journal
- Photochemical & Photobiological Sciences
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1007/s43630-026-00862-8
- Primary Topic
- Photodynamic Therapy Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universiteit Utrecht
- School of Medicine, Indiana University