Cover Feature: Engineering Cumene Dioxygenase for Regioselective Hydroxylation of Monoterpenes and Monoterpenoids (Adv. Synth. Catal. 4/2026)

Engineering Cumene Dioxygenase The painted design by Fátima Navarro-Cetina and WesWizzArt depicts the cumene dioxygenase-catalyzed hydroxylation of monoterpenes. Engineering of this enzyme (depicted as a figurine) yielded variants exhibiting exceptional regioselective control and product formation across various monoterpenes and monoterpenoids, including α-pinene and limonene (stylized as the stems of pine and lemon trees), producing highly sought-after fragrance compounds (depicted in the branches of the corresponding trees). More information can be found in the Research Article by Bernhard Hauer and co-workers (10.1002/adsc.70323).