Chrodrimanins U and V, meroterpenoids from an <i>Alternaria</i> sp.
Two new meroterpenoids, chrodrimanins U and V (<b>1</b> and <b>2</b>), and two known compounds 3-hydroxypentacecilide A (<b>3</b>) and chrodrimanin T (<b>4</b>) were obtained from the ascomycete fungus <i>Alternaria</i> sp. Structural characterisation was achieved through integrated spectroscopic techniques. The absolute configuration of each new meroterpenoid (<b>1</b> and <b>2</b>) was assigned <i>via</i> ECD calculations, respectively. None of the compounds (<b>1</b>-<b>4</b>) displayed cytotoxicity. In contrast, compounds <b>1</b> and <b>3</b> exhibited moderate inhibitory activity against H1N1, with IC<sub>50</sub> values of 52.2 and 58.4 <i>μ</i>M, respectively.
Authors
- Tingnan Zhou
- Peinan Fu (ORCID: https://orcid.org/0000-0003-0709-900X)
- Liancheng Liu (ORCID: https://orcid.org/0009-0007-8470-197X)
- Jie Li (ORCID: https://orcid.org/0000-0002-4366-7724)
- Feng Guo (ORCID: https://orcid.org/0000-0002-0067-3008)
- Zhiyang Lv
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Jiangsu Food and Pharmaceutical Science College (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1080/14786419.2026.2630361
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00