Defining response-adapted surgery after neoadjuvant systemic therapy in sinonasal squamous cell carcinoma
The proposed system introduces the first response-adapted surgery classification to encompass patients with locoregionally advanced sinonasal SCC treated with neoadjuvant therapy prior to definitive surgical resection. By extending standardized terminology, this framework enhances communication within multidisciplinary teams, enables meaningful comparisons across published studies, and supports consistency in developing clinical trial endpoints seeking to balancing oncologic control and functional preservation.
Authors
- David G. Pfister (ORCID: https://orcid.org/0000-0002-2109-3221)
- Kenric Tam (ORCID: https://orcid.org/0000-0003-3203-3280)
- Jennifer R. Cracchiolo (ORCID: https://orcid.org/0000-0003-4496-906X)
- Jacklyn Cho (ORCID: https://orcid.org/0000-0001-5755-204X)
- Lara Ann Dunn (ORCID: https://orcid.org/0000-0001-5318-2571)
- Daniel William Scholfield (ORCID: https://orcid.org/0000-0001-7784-1244)
- Michael T. Starc
- R. Lu (ORCID: https://orcid.org/0000-0001-7123-7556)
- Fergal Kavanagh (ORCID: https://orcid.org/0000-0001-8234-4744)
- Jonas A. Nelson (ORCID: https://orcid.org/0000-0003-0329-4422)
- Viviane Tabar (ORCID: https://orcid.org/0000-0002-1284-1670)
- Farooq Shahzad (ORCID: https://orcid.org/0000-0001-7758-8015)
- Yao Yu
- Evan Matros (ORCID: https://orcid.org/0000-0002-8864-4083)
- Snjezana Doğan
- Nadeem Riaz
- Richard J. Wong
- Winston Wong
- Robert J. Allen
- Sasan Karimi
- Nancy Y. Lee
- Marc A. Cohen
- David Della Rocca
- Kenneth L. Kronstadt
- Sean M. McBride
- Alan Ho
Institutions
- Memorial Sloan Kettering Cancer Center (US)
Publication Details
- Journal
- Oral Oncology
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1016/j.oraloncology.2026.107882
- Primary Topic
- Head and Neck Surgical Oncology
- Type
- article
- Field-Weighted Citation Impact
- 0.00