Can maternal abnormalities in glucose and lipid metabolism reduce the risk of obesity in offspring through breastfeeding, vitamin D, and sleep guidance? a cohort study

Mothers with abnormal glucose and lipid metabolism during pregnancy are at a higher risk of metabolic disorders in their children. This study investigates whether interventions such as feeding practices, sleep management, and vitamin D supplementation can mitigate the risk of obesity in their offspring. We are conducting an ongoing cohort study aimed at determining whether a combination of feeding, sleep, and vitamin D can reduce the risk of obesity in children born to mothers with abnormal glucose and lipid metabolism.We plan to recruit 1,000 pregnant women and their offspring who are at risk for glucose and lipid metabolism disorders. Participants will receive guidance on optimal feeding practices, sleep duration, and vitamin D supplementation for their children. This study has been registered in the Chinese Clinical Trial Registry (ChiCTR240008953). We will assess the risk of obesity in the offspring at 6 months, 12 months, and 24 months of age. The primary outcome measure will be neonatal obesity, while secondary outcome measures will include neonatal blood glucose levels, insulin, C-peptide (C-P), total triglycerides (TG), total cholesterol (TC), and high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) at the three time points post-birth.