Exploring pathways leading to drug‐resistant epilepsy for patients with cryptogenic new onset refractory status epilepticu <scp>s</scp>
Innate immune activation is a hallmark of acute cNORSE but largely resolves in the chronic phase, arguing against persistent innate inflammation as the driver of post-cNORSE epilepsy. In contrast, persistently elevated NfL levels suggest ongoing axonal injury, potentially contributing to poor outcomes. Integrating inflammatory and neuroaxonal injury biomarkers may improve risk stratification and guide long-term management.
Authors
- Elena Pasini (ORCID: https://orcid.org/0000-0002-1069-892X)
- Marissa Kellogg (ORCID: https://orcid.org/0000-0001-7809-7082)
- Clémence Marois (ORCID: https://orcid.org/0000-0002-3266-0623)
- Mario Chávez (ORCID: https://orcid.org/0000-0003-0390-4833)
- Giada Giovannini (ORCID: https://orcid.org/0000-0002-3585-5872)
- Véronique Masson
- Krista Eschbach (ORCID: https://orcid.org/0000-0002-4249-338X)
- Margaux Cheval (ORCID: https://orcid.org/0000-0002-9488-4868)
- Teneille Gofton
- Margaret Gopaul (ORCID: https://orcid.org/0000-0002-1329-3258)
- O. Taraschenko
- Jérôme Alexandre Denis (ORCID: https://orcid.org/0000-0002-1617-4617)
- Rana Alkouri (ORCID: https://orcid.org/0000-0002-7376-4656)
- L. Cousyn
- Martin Guillemaud (ORCID: https://orcid.org/0009-0002-2523-8712)
- Foudil Lamari
- Aurore Besnard
- Aurélie Hanin
- Stefano Meletti
- Nathan Torcida
- Léa Cosme
- Zineb Hayatou
- Ji Yeoun Yoo
- Vincent Navarro
- Nora Wong
- Mark S. Wainwright
- Gwen Goudard
- Raquel Farias‐Moeller
- Francesca Bisulli
- Lawrence J. Hirsch
- Elizabeth E. Gerard
- Dominique Bonnefont‐Rousselot
Institutions
- Northwestern University (US)
- Western University (CA)
- Children's Hospital of Wisconsin (US)
- Centre National de la Recherche Scientifique (FR)
- Université Libre de Bruxelles (BE)
- Inserm (FR)
- Oregon Health & Science University (US)
- University of Washington (US)
- Université Paris Cité (FR)
- London Health Sciences Centre (CA)
- Yale University (US)
- Sorbonne Université (FR)
- Centre National pour la Recherche Scientifique et Technique (CNRST) (MA)
- Azienda Unita' Sanitaria Locale Di Modena (IT)
- Children's Hospital Colorado (US)
- Assistance Publique – Hôpitaux de Paris (FR)
- Azienda Ospedaliero-Universitaria di Modena (IT)
- Pitié-Salpêtrière Hospital (FR)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Centre de Recherche Saint-Antoine (FR)
- Institut du Cerveau (FR)
- University of Nebraska Medical Center (US)
- National Operating Committee on Standards for Athletic Equipment (US)
- University of Colorado Denver (US)
- University of Bologna (IT)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1002/epi.70146
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00