Association of endotheliopathy and coagulopathy biomarkers with survival in a swine model of isolated uncontrolled hemorrhage

These results suggest that acute fatalities undergo hyperfibrinolysis followed by glycocalyx shedding. Survivors may experience longer term complications due to delayed/on-going inflammation and/or endothelium activation. This characterization of severe hemorrhage provides insights into the nature and progression of coagulopathy and endotheliopathy that emulate clinical findings which can be used for evaluating future therapeutics to reduce preventable deaths.