Alterations in energy production in a Drosophila model for the X-linked dystonia-parkinsonism-related Taf1 deficiency

<i>β</i>-oxidation is elevated in flies with severe TAF1 reduction but not detected in XDP-patient fibroblasts, suggesting that this compensatory mechanism may only manifest above a critical TAF1 dosage threshold, absent in patient basal conditions. This finding thus suggests that dosage-dependent metabolic responses occur following TAF1 loss.

Authors

Shela Marie Algodon (ORCID: https://orcid.org/0000-0002-4391-4182)
Melissa Vos (ORCID: https://orcid.org/0000-0002-9883-7698)
Philip Seibler (ORCID: https://orcid.org/0000-0002-3496-7194)
Frida Mandik (ORCID: https://orcid.org/0000-0003-2562-5018)
Christine Klein

Institutions

University of Lübeck (DE)

Publication Details

Journal: Frontiers in Aging Neuroscience
Published: 2026-02-16
DOI: https://doi.org/10.3389/fnagi.2026.1684267
Primary Topic: Neurological disorders and treatments
Type: article
Field-Weighted Citation Impact: 0.00

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article

Alterations in energy production in a Drosophila model for the X-linked dystonia-parkinsonism-related Taf1 deficiency

Shela Marie Algodon, Melissa Vos, Philip Seibler, Frida Mandik et al.

Feb 16, 2026

Frontiers in Aging Neuroscience

Neurological disorders and treatments

article

Alterations in energy production in a Drosophila model for the X-linked dystonia-parkinsonism-related Taf1 deficiency

Shela Marie Algodon, Melissa Vos, Philip Seibler, Frida Mandik, Christine Klein

February 16, 2026article en

Abstract

<i>β</i>-oxidation is elevated in flies with severe TAF1 reduction but not detected in XDP-patient fibroblasts, suggesting that this compensatory mechanism may only manifest above a critical TAF1 dosage threshold, absent in patient basal conditions. This finding thus suggests that dosage-dependent metabolic responses occur following TAF1 loss.

Frontiers in Aging NeuroscienceVol. 18

University of Lübeck (DE)

Affordable and clean energy

Openalex Percentile: Top 57%

Neurological disorders and treatments

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