Unveiling the Modern Therapeutic Properties and Folk Medicinal Riches of Rubia cordifolia

Rubia cordifolia (Manjishtha), a perennial herb of the Rubiaceae family, has been valued in traditional medicine for its diverse pharmacological properties. Predominantly cultivated in hilly regions, its roots have been historically used for their red pigment and therapeutic applications in Ayurveda. R. cordifolia has been traditionally employed for skin diseases, menstrual disorders, snake bites, herpes, eye diseases, haemorrhoids, and fractures. Modern research highlights its potent antioxidant, antimicrobial, and hepatoprotective properties, with evidence supporting its role in managing acne, inflammation, cancer, diabetes, Alzheimer’s disease, and infectious diseases. Furthermore, its integration into various Ayurvedic formulations emphasizes its clinical significance. A comprehensive literature review highlights its bioactive compounds and their therapeutic relevance in modern medicine. The review aims to provide a comprehensive knowledge of the pharmacological impacts, the active components, and the medicinal applications of R. cordifolia. It uncovers new bioactive compounds, mechanisms of action, or novel formulations, patent protection becomes essential.