Transforming growth factor-β1 downregulates tryptophanyl-tRNA synthetase expression in human lung fibroblasts
Our results demonstrate that TGF-β1 inhibits WARS expression via YY1, however, WARS treatment has a modest effect on regulating profibrotic responses in activated HLFs.
Authors
- Konstantin Tsoyi (ORCID: https://orcid.org/0000-0001-5843-5427)
- Aaron K. McDowell-Sanchez
Institutions
- University of Maryland, Baltimore (US)
- Baylor College of Medicine (US)
- Pulmonary and Critical Care Associates (US)
Publication Details
- Journal
- Advances in Medical Sciences
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1016/j.advms.2026.02.002
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00