Paradox of hepatitis B: Metabolic risk and cardiovascular protection in a national cohort
Chronic HBV infection presents a distinct clinical paradox: increased metabolic risk but reduced cardiovascular events. These findings suggest complex immune-metabolic interactions. Clinical management should address both the hepatic burden and the elevated metabolic risks, despite the apparent cardiovascular protection.
Authors
- Chun-Wen Cheng (ORCID: https://orcid.org/0000-0001-9891-2953)
- Chien‐Hao Huang (ORCID: https://orcid.org/0000-0003-1689-3221)
- Shang‐Hung Chang (ORCID: https://orcid.org/0000-0003-0462-2344)
- Shao-Wei Chen (ORCID: https://orcid.org/0000-0003-1674-1295)
- Michael Wu
- Yu-Sheng Lin
- Chun-Li Wang
- Hui-Tzu Tu
- Wei-Lun Chen
- Victor Chien-Chia Wu
- Pao-Hsien Chu
Institutions
- Chang Gung University (TW)
- Brown University (US)
- Chang Gung Memorial Hospital (TW)
- Chiayi Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- International Journal of Cardiology Cardiovascular Risk and Prevention
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1016/j.ijcrp.2026.200599
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chang Gung Memorial Hospital
- Chang Gung Medical Foundation
- Chang Gung Memorial Hospital, Linkou
- Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital
- Center for Big Data Analytics, University of Texas at Austin