Electrochemical Synthesis of 1,2-Substituted <i>N</i> -Amido Benzimidazoles by Reduction of Nitroarenes
Despite the vast number of reports on benzimidazoles, 1,2-substituted <i>N</i>-amido benzimidazoles remain an underrepresented and scarcely accessible compound class with promising pharmacological relevance. We present a safe, reliable electrochemical protocol that provides easy access to those structures. The reaction exhibits broad functional group tolerance and affords the target compounds in ≤89% yields.
Authors
- Thomas Weyhermüller (ORCID: https://orcid.org/0000-0002-0399-7999)
- Daniel Doellerer (ORCID: https://orcid.org/0000-0001-8973-9968)
- Aaron Schüll
- Sebastian B. Beil (ORCID: https://orcid.org/0000-0003-0373-3843)
- Siegfried R. Waldvogel (ORCID: https://orcid.org/0000-0002-7949-9638)
Institutions
- Karlsruhe Institute of Technology (DE)
- Institute of Molecular Functional Materials (CN)
- Max Planck Institute for Chemical Energy Conversion (DE)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1021/acs.orglett.5c05349
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Fraunhofer-Gesellschaft
- Max-Planck-Gesellschaft