In-vitro evaluation of the proliferative and osteogenic activity of atrophic non-union derived mesenchymal stem cells compared to autologous bone graft derived mesenchymal stem cells
The results emphasize that the in-vitro osteogenic and proliferative activity of atrophic non-union MSCs is not impaired as clinically assumed but the osteogenic potential of atrophic non-union MSCs is in fact significantly higher compared to graft derived MSCs. This might be an important basic-science insight for the optimization of clinical non-union therapies.
Authors
- Tobias Großner (ORCID: https://orcid.org/0000-0001-8953-9384)
- Tim Niklas Bewersdorf (ORCID: https://orcid.org/0000-0002-1188-4791)
- Sebastian Findeisen (ORCID: https://orcid.org/0000-0003-4083-1311)
- Christian Schamberger (ORCID: https://orcid.org/0000-0002-9121-472X)
- Ülrike Sommer (ORCID: https://orcid.org/0009-0002-6698-0884)
- Jakob Hofmann
- Thomas Lingner
- Gerhard Schmidmaier (ORCID: https://orcid.org/0000-0002-6711-7380)
- Laura Boehm
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Genevention (Germany) (DE)
Publication Details
- Journal
- European Journal of Trauma and Emergency Surgery
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1007/s00068-026-03112-9
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bundesministerium für Bildung und Forschung