Risk of ovarian cancer in women with a pathogenic or likely pathogenic variant in NBN: a systematic review and meta-analysis
There is a clear association between an NBN pathogenic variant and ovarian cancer in the White population, and this may be stronger with non-high-grade serous carcinoma compared to high-grade serous carcinoma. Further data are required to confirm the association with family history or establish any association in the non-White population. NBN pathogenic variants could be combined with other nongenetic and genetic (polygenic risk score) ovarian cancer risk factors using complex ovarian cancer risk-prediction models going forward, to identify several NBN-positive women at an ovarian cancer risk level for offering surgical prevention.
Authors
- N. Flaum
- Caitlin T. Fierheller (ORCID: https://orcid.org/0000-0001-9583-3061)
- Priyanka Deshmukh
- Jacqueline Sia (ORCID: https://orcid.org/0000-0002-1820-3194)
- Ashwin Kalra (ORCID: https://orcid.org/0000-0002-5541-226X)
- Samuel Oxley (ORCID: https://orcid.org/0000-0003-1967-813X)
- Michail Sideris (ORCID: https://orcid.org/0000-0002-4199-6700)
- Amanda Dibden (ORCID: https://orcid.org/0000-0002-0599-9840)
- А. Малан
- Subhasheenee Ganesan
- Lea Mansour
- Xia Wei
- Robert D. Morgan
- Hamda Mohamed
- Adam Brentnall
- Ranjit Manchanda
Institutions
- Queen Mary University of London (GB)
- Barts Health NHS Trust (GB)
- Manchester University NHS Foundation Trust (GB)
- The Christie NHS Foundation Trust (GB)
Publication Details
- Journal
- American Journal of Obstetrics and Gynecology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.ajog.2026.02.020
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00