A novel 18F-labelled tetrazine ester prosthetic group for improved radiolabelling and in vivo stability of proteins and peptides
The novel tetrazine prosthetic group [<sup>18</sup>F]TzE2 enabled straightforward radiolabelling of Affibody molecule Z09591 without affecting its binding properties. [<sup>18</sup>F]TzE2-Z09591 showed improved stability and in vivo targeting of PDGFRβ compared with the previously reported tetrazine ester [<sup>18</sup>F]TzE-Z09591. [<sup>18</sup>F]TzE2 represents a promising tetrazine prosthetic group for labelling of proteins and peptides with fluorine-18.
Authors
- Olivia Wegrzyniak (ORCID: https://orcid.org/0000-0001-9636-0390)
- Olof Eriksson (ORCID: https://orcid.org/0000-0002-2515-8790)
- Francesco Lechi
- Lorenzo J. I. Balestri
- Luke R. Odell
- Jonas Eriksson
Institutions
- Uppsala University (SE)
- Uppsala University Hospital (SE)
- Science for Life Laboratory (SE)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1186/s41181-026-00430-6
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00