PPAR-γ Activation Alleviates Intestinal Dysfunction and Lactose Malabsorption in Experimental Food Allergy Rats
PPAR-γ signaling maintains intestinal lactose digestive capacity of rats during allergic inflammation by sustaining lactase production and monosaccharide transporter expression. Our findings verify an immunometabolism mechanism linking nuclear receptor activation to enhanced nutrient absorption and highlight PPAR-γ agonism as a promising therapeutic strategy to alleviate food allergy-associated lactose malabsorption.
Authors
- Zouyan He (ORCID: https://orcid.org/0000-0001-6545-2719)
- Lu Yao
- Yuxin Jin (ORCID: https://orcid.org/0000-0002-6124-9681)
- Sheng Yin (ORCID: https://orcid.org/0000-0002-4481-495X)
- Huilian Che
- Yuyang Hao
Institutions
- Beijing Technology and Business University (CN)
- National Medical Products Administration (CN)
- University College Cork (IE)
- China Agricultural University (CN)
Publication Details
- Journal
- Nutrients
- Published
- 2026-02-16
- DOI
- https://doi.org/10.3390/nu18040653
- Primary Topic
- Digestive system and related health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Agricultural University