Cobalt‐Catalyzed Coupling of 1,3‐Enynes and Acrylates to Access Trisubstituted and Tetrasubstituted Olefins
A general cobalt‐catalyzed oxidative cyclization strategy for the stereoselective synthesis of tri‐ and tetrasubstituted alkenes from readily available 1,3‐enynes is presented. This method employs an earth‐abundant cobalt catalyst and exhibits broad functional group tolerance, delivering the multisubstituted olefins with high regioselectivity and excellent Z / E control.
Authors
- Wenxin Lu (ORCID: https://orcid.org/0000-0001-6388-7743)
- Lina Ma (ORCID: https://orcid.org/0000-0002-0104-1934)
- J. W. HUANG
- Changliang Tan
- Fanke Meng
- Qinglei Chong
- Liang‐Hua Zou
Institutions
- Jiangnan University (CN)
- Purdue University West Lafayette (US)
- Shanghai Institute of Organic Chemistry (CN)
- University of Chinese Academy of Sciences (CN)
- Nanjing University (CN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2026-02-15
- DOI
- https://doi.org/10.1002/ejoc.202501202
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Science and Technology Commission of Shanghai Municipality
- Beijing National Laboratory for Molecular Sciences