Effect of Perioperative Supplementation with Arginine and Omega-3 on Postoperative Complications in Patients Undergoing Gastrointestinal Cancer Surgery: A Pilot Open-Label Randomized Controlled Trial
In this trial, perioperative immunonutrition with arginine and omega-3 fatty acids did not improve postoperative clinical outcomes or inflammatory markers in patients undergoing gastrointestinal cancer surgery. At the administered dose and within a small, heterogeneous cohort, immunonutrition did not provide additional benefit beyond standard care. Larger, adequately powered multicenter trials with optimized dosing are required to clarify its role in gastrointestinal oncology.
Authors
- Henda Kammoun Jamoussi
- Ines Zemni
- Halil İbrahim Ceylan (ORCID: https://orcid.org/0009-0005-2214-4667)
- T. ben dhiab
- S. Sakhri
- Ismail Dergaa
- Valentina Ștefănică
- Rym Ben Othman
- Nagihan Burçak Ceylan
- Chaima Jerbi
- Lamia Naija
Institutions
- Tunis University (TN)
- Bayburt University (TR)
- Institut Salah-Azaïz (TN)
- Institut National de Nutrition et de Technologie Alimentaire (TN)
- University of Pitesti (RO)
- Faculté de médecine de Tunis
- University of Jendouba (TN)
- Universitatea Națională de Știință și Tehnologie Politehnica București (RO)
- Tunis El Manar University (TN)
- Atatürk University (TR)
- Manouba University (TN)
Publication Details
- Journal
- Nutrients
- Published
- 2026-02-16
- DOI
- https://doi.org/10.3390/nu18040651
- Primary Topic
- Enhanced Recovery After Surgery
- Type
- article
- Field-Weighted Citation Impact
- 0.00