Circulating placental small extracellular vesicles miR-2110 depletion drives maternal-fetal endothelial injury in preeclampsia

We first established the role of the miR-2110/PTPN14/YAP1 pathway regulatory network in PE endothelial cell injury. This mechanism links placental ischemia with endothelial cell injury and long-term cardiovascular risks in both mother and fetus. Our study provides a comprehensive understanding of the sEVs-mediated placenta-endothelium communication axis in PE, and miR-2110 serves as both a mechanistic mediator and an early diagnostic biomarker, offering new insights for targeted interventions and improving adverse outcomes.