Composite regenerative matrix for barrier-free bone regeneration: Full-mouth rehabilitation with long-term stability

We described a novel composite regenerative matrix (CRM) designed to improve the handling and stability of sticky bone and advanced platelet-rich fibrin (PRF). The CRM combined autologous fibrinogen glue, allograft, and type I collagen and was processed through repeated compression cycles to enhance graft cohesion. A patient with generalized advanced periodontitis presented with severe vertical and horizontal alveolar bone loss, including a rare no-wall defect in the anterior mandible was reported in this study. Following periodontal therapy and extraction of unrestorable teeth, the CRM was used for socket regeneration and ridge augmentation without a membrane. Delayed implant placement and full-arch rehabilitation were subsequently performed. Clinical and radiographic outcomes demonstrated substantial vertical bone gain, stable peri-implant tissues, and favorable esthetics. The 6 -year post-operative cone-beam computed tomography confirmed cortical bone formation. Thus, the CRM may provide a clinically feasible and predictable membrane-free option for complex alveolar defects for which conventional guided bone regeneration is limited.