First identification of an ST11-KL64 hypervirulent Klebsiella pneumoniae strain coproducing KPC-2 and NDM-1 with an OmpK36 GD mutation

To our knowledge, this is the first report of a hypervirulent ST11-KL64 <i>K. pneumoniae</i> strain carrying both <i>bla</i> <sub>KPC-2</sub> and <i>bla</i> <sub>NDM-1</sub> with an <i>OmpK36</i> GD mutation. This convergence of plasmid-mediated resistance, chromosomal mutation, and hypervirulence in a high-risk clone highlights an urgent threat requiring increased genomic surveillance.

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Journal
Frontiers in Microbiology
Published
2026-02-16
DOI
https://doi.org/10.3389/fmicb.2026.1755521
Primary Topic
Antibiotic Resistance in Bacteria
Type
article
Field-Weighted Citation Impact
0.00

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article

First identification of an ST11-KL64 hypervirulent Klebsiella pneumoniae strain coproducing KPC-2 and NDM-1 with an OmpK36 GD mutation

Jiaoli Chen, Jianfen Xu, Mei Ya Li, Cheng Wang et al.
Frontiers in Microbiology
Antibiotic Resistance in Bacteria
article

First identification of an ST11-KL64 hypervirulent Klebsiella pneumoniae strain coproducing KPC-2 and NDM-1 with an OmpK36 GD mutation

Jiaoli Chen, Jianfen Xu, Mei Ya Li, Cheng Wang, Lingbin Wu, Jiansheng Huang, Ziling Lan, Xiaolei Hu
article en

Abstract

To our knowledge, this is the first report of a hypervirulent ST11-KL64 <i>K. pneumoniae</i> strain carrying both <i>bla</i> <sub>KPC-2</sub> and <i>bla</i> <sub>NDM-1</sub> with an <i>OmpK36</i> GD mutation. This convergence of plasmid-mediated resistance, chromosomal mutation, and hypervirulence in a high-risk clone highlights an urgent threat requiring increased genomic surveillance.

Frontiers in MicrobiologyVol. 17
Zhejiang Chinese Medical University (CN), Xinjiang Medical University (CN), Wenzhou Medical University (CN), Fifth Affiliated Hospital of Xinjiang Medical University (CN), Lishui City People's Hospital (CN)
National Key Research and Development Program of China, Natural Science Foundation of Zhejiang Province
Openalex Percentile: Top 51%
Antibiotic Resistance in Bacteria
DOIOpen Access PDFOpenAlex
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First identification of an ST11-KL64 hypervirulent Klebsiella pneumoniae strain coproducing KPC-2 and NDM-1 with an OmpK36 GD mutation — Jiaoli Chen, Jianfen Xu, et al. · Frontiers in Microbiology (2026) | TGRS Research Map | TGRS