<i>AKT1</i> but not <i>AKT2</i> single nucleotide polymorphisms are associated with the risk of microscopic polyangiitis
AKT1 emerges from this study as a likely genetic contributor to MPA, with its influence potentially involving neutrophil regulatory functions and vascular maintenance. The consistent absence of association signals for AKT2 across all analytical approaches could be viewed as reinforcing the specificity of AKT1's involvement. These insights help refine the genetic architecture of MPA and position AKT1 signaling as a candidate pathway for future therapeutic exploration.
Authors
- Chao Xue (ORCID: https://orcid.org/0000-0001-5671-1969)
- Liepeng Chu (ORCID: https://orcid.org/0000-0002-7243-6861)
- Yinyin Chen (ORCID: https://orcid.org/0009-0002-5034-404X)
- Jing Yang (ORCID: https://orcid.org/0000-0003-2862-4993)
- Jinlan Rao
- Lizhen Li (ORCID: https://orcid.org/0000-0001-6567-7846)
- Huifang Tan
- You Peng (ORCID: https://orcid.org/0000-0001-9820-093X)
- Shuangshuang Fu
- Wenlv Tang
- Meili Huang
- Kui Tan
- Meijun Xu
Institutions
- Guangxi Medical University (CN)
- Hunan Normal University (CN)
- Hunan Mawangdui Hospital (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- The Second Nanning People's Hospital (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2026-02-16
- DOI
- https://doi.org/10.7717/peerj.20791
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00