Associations of physical frailty with risk of incident cardiovascular disease by mediation of plasma metabolome changes
This study highlights a distinct frailty-related metabolic profile that independently predicts cardiovascular risk and partially mediates the frailty-CVD association. These findings underscore the value of metabolomic profiling in guiding early detection and prevention strategies for frailty-related cardiovascular outcomes.
Authors
- Nayili Mahemuti
- Yinyue Liu
- Xumei Zhang (ORCID: https://orcid.org/0009-0000-3536-8655)
- Yu Lan
- Xiaolong Xing
- Guangbin Sun
- Rui Xi
- Xueli Yang
- Ao Sun
- Qiang Zhang
Institutions
- Nankai University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- The Journals of Gerontology Series A
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1093/gerona/glag035
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 0.00