Bioinformatic Identification and Preliminary Validation of TP53, TGFB1, and NFE2L2 as Potential Ferroptosis-Related Regulators in Pancreatic Adenocarcinoma
TP53, TGFB1, and NRF2 are key ferroptosis-related regulators in PAAD, influencing tumor progression, ferroptosis sensitivity, and immune contexture. These findings provide new insights and potential targets for ferroptosis-based therapies in PAAD.
Authors
- Dazhou Xu
- Z X Zhang
- Tonglei Xu
- Shengxiang Lv (ORCID: https://orcid.org/0000-0003-4827-2542)
- Shouying Li
- Chunfang Zhang
Institutions
- Zhongda Hospital Southeast University (CN)
- The First People’s Hospital of Lianyungang (CN)
Publication Details
- Journal
- Pharmacogenomics and Personalized Medicine
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/pgpm.s562602
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00