Clinical Efficacy of Acupuncture for Knee Osteoarthritis and Associated Changes in Serum Lipidomics: A Prospective Observational Cohort Study
Acupuncture significantly improved pain and function in KOA and modulated serum lipid metabolism. Regulation of phosphatidylethanolamine (PE), lysophosphatidylcholine (LPC), lysophosphatidylethanolamine (LPE), and triglycerides (TG), together with enrichment of related pathways, suggests that acupuncture restores lipid homeostasis and alleviates inflammation, supporting its metabolic therapeutic role in KOA.
Authors
- Xiaoyang Lian
- Xinyu Li (ORCID: https://orcid.org/0000-0001-9358-4647)
- Xiaojie Li (ORCID: https://orcid.org/0000-0003-2097-7196)
- Guangxia Ni
- Dong Chen
- Min Xu
- Hui Zhang
- Na Xue
- Xiaoying Wang
Institutions
- Nanjing University of Chinese Medicine (CN)
- Jiangsu Vocational College of Medicine (CN)
Publication Details
- Journal
- Journal of Pain Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/jpr.s578343
- Primary Topic
- Acupuncture Treatment Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province