ESCMID clinical guidelines on the evaluation and management of a reported antibiotic allergy

The guideline recommends a structured clinical assessment to evaluate a reported antibiotic allergy, taking into consideration the characteristics of the index reaction. Where the clinical history suggests a very low or low likelihood of true allergy, direct delabelling or performing a controlled drug challenge test is appropriate. By supporting allergy evaluation and prudent prescribing practices, the recommendations aim to improve individual patient outcomes and reinforce antimicrobial stewardship goals.

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Institutions

Publication Details

Journal
Clinical Microbiology and Infection
Published
2026-02-01
DOI
https://doi.org/10.1016/j.cmi.2026.02.011
Citations
1
Primary Topic
Drug-Induced Adverse Reactions
Type
article
Field-Weighted Citation Impact
32.57

Funders

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article

ESCMID clinical guidelines on the evaluation and management of a reported antibiotic allergy

Anca Mirela Chiriac, Sílvia Gómez-Zorrilla, Jason A. Trubiano, Roos Wijnakker et al.
1 citations
Clinical Microbiology and Infection
Drug-Induced Adverse Reactions
32.57
article

ESCMID clinical guidelines on the evaluation and management of a reported antibiotic allergy

Anca Mirela Chiriac, Sílvia Gómez-Zorrilla, Jason A. Trubiano, Roos Wijnakker, Kimberly G. Blumenthal, Neil Powell, Eleni Karakike, Oana Joean, Kevin Sermet, Liat Ashkenazi-Hoffnung, Yasemin Cakir Kiymaz, Mark G.J. De Boer, Elham Khatamzas, Jonathan Sandoe, Cecilia Bonazzetti, Blin Nagavci
article en
1 citations

Abstract

The guideline recommends a structured clinical assessment to evaluate a reported antibiotic allergy, taking into consideration the characteristics of the index reaction. Where the clinical history suggests a very low or low likelihood of true allergy, direct delabelling or performing a controlled drug challenge test is appropriate. By supporting allergy evaluation and prudent prescribing practices, the recommendations aim to improve individual patient outcomes and reinforce antimicrobial stewardship goals.

Clinical Microbiology and Infection
Sivas Cumhuriyet Üniversitesi (TR), Universitat Pompeu Fabra (ES), National and Kapodistrian University of Athens (GR), Heidelberg University (DE), Université de Lille (FR), Leeds Teaching Hospitals NHS Trust (GB), Royal Cornwall Hospital Trust (GB), Leiden University Medical Center (NL), Jacksonville College (US), University Hospital Heidelberg (DE), Centre Hospitalier Universitaire de Montpellier (FR), National Institute for Public Health and the Environment (NL), Schneider Children's Medical Center (IL), Azienda USL di Bologna (IT), Jena University Hospital (DE), European Society of Clinical Microbiology and Infectious Diseases (CH), Austin Health (AU), Friedrich Schiller University Jena (DE)
European Society of Clinical Microbiology and Infectious Diseases, Universiteit Leiden, Leids Universitair Medisch Centrum
Openalex Percentile: Top 1%
Drug-Induced Adverse Reactions
32.57
DOIOpen Access PDFOpenAlex
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