A novel culture flask for clinostat-based simulation of extraterrestrial gravities
The latter one provides a reproducible and relevant baseline, avoiding confounding factors related to O<sub>2</sub> delivery for clinostat-based simulations. The F-25 flask setup, which allows controlled oxygenation and minimized hydrostatic artifacts, offers a versatile platform not only for space biology, but also for hypoxia studies, 3D culture systems, and tissue engineering applications requiring a defined O<sub>2</sub> microenvironment.
Authors
- Paolo Follesa (ORCID: https://orcid.org/0000-0003-4857-476X)
- Alessandro Concas (ORCID: https://orcid.org/0000-0003-4034-656X)
- Giacomo Cao (ORCID: https://orcid.org/0000-0002-5307-0016)
- Giacomo Fais (ORCID: https://orcid.org/0000-0003-3918-0400)
- Debora Dessì
- Giovanni Perra
Institutions
- University of Cagliari (IT)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-02-16
- DOI
- https://doi.org/10.3389/fcell.2026.1728827
- Primary Topic
- Spaceflight effects on biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00