Anti-ASC antibodies alleviate Alzheimer’s disease–type pathology in APP/PS1 mice
The anti-ASC N-terminal and C-terminal antibodies may have neuroprotective effects, which are manifested as reducing cell apoptosis, improving cognitive function, and alleviating AD-like pathology in AD mice. Immunotherapies targeting ASC are promising for treating AD.
Authors
- Long Yan
- Liu He
- Zhu Xiaopeng
- Deng Juan
Institutions
- Army Medical University (CN)
- Daping Hospital (CN)
Publication Details
- Journal
- Neuroscience
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1016/j.neuroscience.2026.02.023
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00