H3.3 G34R-engineered murine glioma reproduces diffuse perineuronal infiltration of diffuse hemispheric glioma, H3 G34-mutant
Our H3.3 G34R-engineered murine model successfully reproduces the defining neurotropic features of human DHG-H3G34, particularly PS. This pathologically relevant model provides a valuable platform for investigating the molecular basis of glioma invasion and for guiding the development of therapeutic strategies.
Authors
- Hiroyuki Tomita (ORCID: https://orcid.org/0000-0002-3291-0274)
- Takafumi Okubo
- Yuko Imaizumi
- Shigeyuki Sugie (ORCID: https://orcid.org/0000-0002-4309-7987)
- Tomohiro Kanayama (ORCID: https://orcid.org/0000-0001-8845-6827)
- Takahide Taniguchi (ORCID: https://orcid.org/0000-0003-3723-0945)
- Aoi Muto
- Masafumi Miyai (ORCID: https://orcid.org/0000-0002-2885-2331)
- Ayumi Niwa
- Kosuke Mori (ORCID: https://orcid.org/0000-0002-2992-056X)
- Hiroki Suzuki
- Koki Ichihashi
- Akira Hara
- Tsuyoshi Izumo
Institutions
- Asahi University (JP)
- Gifu University Hospital (JP)
- Gifu University (JP)
Publication Details
- Journal
- Biochemical and Biophysical Research Communications
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1016/j.bbrc.2026.153471
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00