Human Cytomegalovirus Shedding and T-cell Immune Responses in HCMV-seropositive Women During Pregnancy and Postpartum: Prevalence, Natural History, and Risk Factors
Around 1 in 5 HCMV-seropositive women shed HCMV during pregnancy and postpartum. Ethnicity and gravidity are associated with shedding, but not T-cell immune responses, and the quantity of shedding is associated with contact with saliva. Further studies investigating HCMV shedding, immune responses and their risk factors in women during pregnancy and postpartum are warranted.
Authors
- Vanessa Greening
- Miao Tang (ORCID: https://orcid.org/0000-0002-5980-6207)
- D Carrington
- Shari Sapuan (ORCID: https://orcid.org/0000-0001-7648-4601)
- Paul T. Heath
- Sarah White
- Christine E Jones
- Cassie F Pope
- Asma Khalil
Institutions
- St George's, University of London (GB)
- Manchester Academic Health Science Centre (GB)
- St George’s University Hospitals NHS Foundation Trust (GB)
- University of Manchester (GB)
- St George's Hospital (GB)
- NIHR Southampton Biomedical Research Centre (GB)
- University of Southampton (GB)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1093/cid/ciag076
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00