Loss of Myonuclei and Transcriptional Activity During Diaphragm Atrophy in Critically Ill Patients
We identified myonuclear loss due to intrinsic apoptotic pathway activation as a potential mechanism underlying diaphragm atrophy in mechanically ventilated patients. The loss of myonuclei may contribute to impaired regeneration of myofibers after critical illness. Duration and mode of mechanical ventilation are not the major drivers of these modifications.
Authors
- R. Boon
- Sylvia J. P. Bogaards (ORCID: https://orcid.org/0000-0002-7127-3458)
- L M A Heunks
- Gerben Schaaf (ORCID: https://orcid.org/0000-0003-0189-9073)
- Tyler J. Kirby (ORCID: https://orcid.org/0000-0002-0210-3826)
- Marloes van den Berg (ORCID: https://orcid.org/0000-0003-0920-6139)
- R. Baelde (ORCID: https://orcid.org/0009-0006-3331-2985)
- Coen A. C. Ottenheijm (ORCID: https://orcid.org/0000-0002-8808-4813)
- Heleen Hakkeling
- Arezou Bamyani
- Luuk Bonis
- Zhong Shi
- Wout J. Claassen
- Chris Dickhoff
- Albertus Beishuizen
Institutions
- University of Arizona (US)
- University of Kentucky (US)
- Radboud University Nijmegen (NL)
- Medisch Spectrum Twente (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- Amsterdam Neuroscience (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- Amsterdam University Medical Centers (NL)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/jcsm.70228
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- ZonMw
- National Heart, Lung, and Blood Institute
- National Institute of Arthritis and Musculoskeletal and Skin Diseases