Prediction of Left Atrial Volume Parameters from Resting ECGs and Tabular Data Using Deep Learning in the UK Biobank

We present a deep learning model that predicts left atrial (LA) volume from standard 12-lead ECG recordings and basic patient data. This approach offers a low-cost, scalable alternative to MRI-based LA volume measurement, which remains the clinical gold standard but is often inaccessible. Our model performs regression directly on LA volume targets and leverages Shapley values to provide interpretable feature importance. Results highlight the predictive value of ECG signals and demonstrate that patient features such as weight and height contribute meaningfully to the estimation.

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Publication Details

Journal
medRxiv
Published
2026-02-16
DOI
https://doi.org/10.64898/2026.02.13.26346205
Primary Topic
Atrial Fibrillation Management and Outcomes
Type
article
Field-Weighted Citation Impact
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article

Prediction of Left Atrial Volume Parameters from Resting ECGs and Tabular Data Using Deep Learning in the UK Biobank

Zareen Farukhi, David Brüggemann, Olga Demler, Moritz Dieing
medRxiv
Atrial Fibrillation Management and Outcomes
article

Prediction of Left Atrial Volume Parameters from Resting ECGs and Tabular Data Using Deep Learning in the UK Biobank

Zareen Farukhi, David Brüggemann, Olga Demler, Moritz Dieing
article en

Abstract

We present a deep learning model that predicts left atrial (LA) volume from standard 12-lead ECG recordings and basic patient data. This approach offers a low-cost, scalable alternative to MRI-based LA volume measurement, which remains the clinical gold standard but is often inaccessible. Our model performs regression directly on LA volume targets and leverages Shapley values to provide interpretable feature importance. Results highlight the predictive value of ECG signals and demonstrate that patient features such as weight and height contribute meaningfully to the estimation.

medRxiv
Brigham and Women's Hospital (US), ETH Zurich (CH), Massachusetts General Hospital (US), Swiss Data Science Center (CH)
Openalex Percentile: Top 57%
Atrial Fibrillation Management and Outcomes
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