Early immunosuppression therapy improves outcomes in CD8+ T‐cell activated paediatric acute liver failure and hepatitis
Evaluation of liver immunohistochemistry and peripheral T-cell subset analysis is essential for identification of patients with PALF and hepatitis with CD8+ T-cell predominant liver injury. Early CS and adjunct IS are safe and effective in achieving favourable outcomes at 24 months.
Authors
- Prerna Diksha
- Kathleen McGrath (ORCID: https://orcid.org/0000-0003-0016-6441)
- Winita Hardikar (ORCID: https://orcid.org/0000-0003-4277-2773)
- Jack Hywood (ORCID: https://orcid.org/0000-0002-2028-2629)
- George Alex (ORCID: https://orcid.org/0000-0002-5157-8983)
- Mark R Oliver
- Jason Yap
- Elizabeth Bannister
- Shaun S. C. Ho
Institutions
- Royal Children's Hospital (AU)
- The University of Melbourne (AU)
- Murdoch Children's Research Institute (AU)
Publication Details
- Journal
- Journal of Pediatric Gastroenterology and Nutrition
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1002/jpn3.70374
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00