Low-density lipoprotein cholesterol, coronary plaque burden, and myocardial infarction in adults aged 76–92 years: the Western Denmark Heart Registry

In statin-naïve symptomatic individuals aged 76-92, higher LDL-C was associated with CAC >90th percentile, post-CCTA revascularization, and increased risk of MI. These findings suggest that elevated LDL-C is a driver of coronary artery disease throughout life.

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Publication Details

Journal
European Journal of Preventive Cardiology
Published
2026-02-13
DOI
https://doi.org/10.1093/eurjpc/zwag108
Primary Topic
Lipoproteins and Cardiovascular Health
Type
article
Field-Weighted Citation Impact
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article

Low-density lipoprotein cholesterol, coronary plaque burden, and myocardial infarction in adults aged 76–92 years: the Western Denmark Heart Registry

Pernille Gro Thrane, Kevin Kris Warnakula Olesen, Martin Busk, Malene Kærslund Hansen et al.
European Journal of Preventive Cardiology
Lipoproteins and Cardiovascular Health
article

Low-density lipoprotein cholesterol, coronary plaque burden, and myocardial infarction in adults aged 76–92 years: the Western Denmark Heart Registry

Pernille Gro Thrane, Kevin Kris Warnakula Olesen, Martin Busk, Malene Kærslund Hansen, Malene Højgaard Andersen, NPR Sand, Michael Maeng, J M Jensen, H Lynge Kanstrup, Martin Bødtker Mortensen, Michael J Blaha, Bjarne Linde Nørgaard, Børge G Nordestgaard
article en

Abstract

In statin-naïve symptomatic individuals aged 76-92, higher LDL-C was associated with CAC >90th percentile, post-CCTA revascularization, and increased risk of MI. These findings suggest that elevated LDL-C is a driver of coronary artery disease throughout life.

European Journal of Preventive Cardiology
University of Copenhagen (DK), Johns Hopkins University (US), University of Southern Denmark (DK), Johns Hopkins Medicine (US), Aarhus University Hospital (DK), Gentofte Hospital (DK), Region of Southern Denmark (DK), Hospital South West Jutland (DK), Lillebaelt Hospital (DK)
Good health and well-being
Openalex Percentile: Top 54%
Lipoproteins and Cardiovascular Health
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Low-density lipoprotein cholesterol, coronary plaque burden, and myocardial infarction in adults aged 76–92 years: the Western Denmark Heart Registry — Pernille Gro Thrane, Kevin Kris Warnakula Olesen, et al. · European Journal of Preventive Cardiology (2026) | TGRS Research Map | TGRS