Growth Hormone Pathway as a Prognostic and Therapeutic Biomarker in Patients With Unresectable Hepatocellular Carcinoma Treated With Radiation Therapy

In this hypothesis-generating exploratory analysis, high pretreatment GH levels were associated with worse survival outcomes in patients with unresectable HCC undergoing RT. Despite the retrospective design and limited cohort size, these findings provide biologically and clinically relevant preliminary evidence supporting GH as a potential prognostic biomarker. Validation in larger, prospective, multi-institutional cohorts is warranted, and any therapeutic implications related to targeting the GH/GH receptor axis should be considered exploratory.

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Publication Details

Journal
Advances in Radiation Oncology
Published
2026-02-16
DOI
https://doi.org/10.1016/j.adro.2026.102007
Primary Topic
Growth Hormone and Insulin-like Growth Factors
Type
article
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article

Growth Hormone Pathway as a Prognostic and Therapeutic Biomarker in Patients With Unresectable Hepatocellular Carcinoma Treated With Radiation Therapy

Safa A. Kaseb, Mahesh Kumar Kannan, Asif Rashid, Lianchun Xiao et al.
Advances in Radiation Oncology
Growth Hormone and Insulin-like Growth Factors
article

Growth Hormone Pathway as a Prognostic and Therapeutic Biomarker in Patients With Unresectable Hepatocellular Carcinoma Treated With Radiation Therapy

Safa A. Kaseb, Mahesh Kumar Kannan, Asif Rashid, Lianchun Xiao, Joe R Eid, Manal Hassan, Hop S Tran Cao, Hesham M Amin, Ryan Sun
article en

Abstract

In this hypothesis-generating exploratory analysis, high pretreatment GH levels were associated with worse survival outcomes in patients with unresectable HCC undergoing RT. Despite the retrospective design and limited cohort size, these findings provide biologically and clinically relevant preliminary evidence supporting GH as a potential prognostic biomarker. Validation in larger, prospective, multi-institutional cohorts is warranted, and any therapeutic implications related to targeting the GH/GH receptor axis should be considered exploratory.

Advances in Radiation OncologyVol. 11(5)
The University of Texas MD Anderson Cancer Center (US)
Good health and well-being
Openalex Percentile: Top 56%
Growth Hormone and Insulin-like Growth Factors
DOIOpen Access PDFOpenAlex
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