Colchicine inhibits macrophage motility and matrix degradation through microtubule disruption
While msBMM appeared less susceptible to low-dose colchicine than huMDM, there was a measurable effect on their microtubules that resulted in reduced motility. Inhibition of huMDM matrix degradative capacity may contribute to colchicine's effect in reducing cardiovascular events.
Authors
- Julie M. Proudfoot
- Fiona J. Pixley (ORCID: https://orcid.org/0000-0002-1571-2532)
- Carl Schultz (ORCID: https://orcid.org/0000-0002-0847-4361)
- Aaron L. Magno (ORCID: https://orcid.org/0000-0001-6099-819X)
- Mansi Vansjariya
Institutions
- The University of Western Australia (AU)
- Royal Perth Hospital (AU)
Publication Details
- Journal
- Vascular Pharmacology
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1016/j.vph.2026.107587
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00