Modest neurodevelopment impacts of APOE4 in a human brain organoid model of low-grade SARS-CoV-2 infection
Taken together, this study suggests that APOE4 modulates region-specific responses to low-grade SARS-CoV-2 infection, underscoring the importance of exploring how genetic risk factors alter neurodevelopmental vulnerability to prenatal viral infection.
Authors
- Karina K. Meyer-Acosta
- Adyasha Aruk
- Aranis Muniz-Perez
- Courtney Lee McMahon
- Varsha Ponnala
- Jenny Hsieh
- Samhitha Boyana
- Amber Elizalde
Publication Details
- Journal
- Developmental Neuroscience
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1159/000550957
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Texas at San Antonio
- Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation
- National Institutes of Health