Integrative Oncology for Biochemical Recurrence of Epithelial Ovarian Cancer

Mind-body therapies, including mindfulness, yoga, and cognitive behavioral therapy, have demonstrated benefits in reducing anxiety, distress, and fear of recurrence. Exercise and acupuncture improve vitality, mood, and sleep. Nutritional strategies-particularly anti-inflammatory diets, vitamin D sufficiency, and omega-3 fatty acid intake-promote resilience and overall health. Natural compounds such as green tea, medicinal mushrooms, modified citrus pectin, melatonin, and AHCC show immune-modulating or anti-tumor effects in preclinical or early clinical studies. Among repurposed non-oncologic drugs, metformin provides the strongest rationale, especially for women with type 2 diabetes. Although ovarian cancer-specific trials are limited, IO approaches are safe, feasible, and evidence-informed. They address psychosocial distress, improve quality of life, and may influence disease biology, offering meaningful options for women under surveillance during biochemical recurrence.