Diagnostic Utility of Ki‐67 Index on Cell Block Material for Grading Medullary Thyroid Carcinoma

Grading MTC using the Ki-67 proliferation index on cell blocks is challenging because of low cellularity and intratumoral heterogeneity in Ki-67 expression. In our study, this approach tended to undergrade high-grade MTC.

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Publication Details

Journal
Diagnostic Cytopathology
Published
2026-02-16
DOI
https://doi.org/10.1002/dc.70102
Primary Topic
Thyroid Cancer Diagnosis and Treatment
Type
article
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article

Diagnostic Utility of Ki‐67 Index on Cell Block Material for Grading Medullary Thyroid Carcinoma

Brent Molden, Hector Mesa, Bianca Puello, Tieying Hou
Diagnostic Cytopathology
Thyroid Cancer Diagnosis and Treatment
article

Diagnostic Utility of Ki‐67 Index on Cell Block Material for Grading Medullary Thyroid Carcinoma

Brent Molden, Hector Mesa, Bianca Puello, Tieying Hou
article en

Abstract

Grading MTC using the Ki-67 proliferation index on cell blocks is challenging because of low cellularity and intratumoral heterogeneity in Ki-67 expression. In our study, this approach tended to undergrade high-grade MTC.

Diagnostic Cytopathology
University of Maryland, Baltimore (US), AmeriQual Group (United States) (US), Indiana University School of Medicine, Indiana University – Purdue University Indianapolis (US)
Openalex Percentile: Top 56%
Thyroid Cancer Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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