Boron-Mediated C1-Hydroxylation of Carbazoles Using Benzoyl as the Traceless Directing Group
Herein, a metal-free BBr<sub>3</sub>-mediated C-H hydroxylation of carbazoles using benzoyl as a traceless directing group has been reported. This protocol features high efficiency and operational simplicity, offering the valuable 1-hydroxycarbazoles in moderate to excellent yields with scale-up ability under mild conditions. In addition, this transformation can be performed in one-pot, which is highlighted by the utility for the total synthesis of carbazole alkaloid murrayaquinone A.
Authors
- Miao Tian (ORCID: https://orcid.org/0000-0002-7013-2071)
- Kai Sun (ORCID: https://orcid.org/0000-0002-2577-4585)
- Zexuan Zhang
- Jianfeng Tao
- Huiwen Zheng (ORCID: https://orcid.org/0000-0002-6056-3468)
- Na Xie
- Tao Zhou
- Minghan Li
- Zixian Wei
Institutions
- Yantai University (CN)
- State Key Laboratory of Pollution Control and Resource Reuse (CN)
- Nanchang Hangkong University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1021/acs.joc.5c02691
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00