Management of the newborn at risk for vertical sepsis

Suspected early-onset sepsis (EOS) is one of the most frequent diagnoses in neonatal units; however, infection is not confirmed in most cases, leading to the widespread overuse of empirical antibiotherapy. This document presents a diagnostic and therapeutic approach to EOS and proposes evidence-based recommendations, supported by national epidemiological data, for the management of neonates at risk of EOS according to gestational age and individual risk level, in order to promote rational use of antibiotics in the neonatal period.

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Publication Details

Journal
Anales de Pediatría (English Edition)
Published
2026-02-01
DOI
https://doi.org/10.1016/j.anpede.2026.504106
Primary Topic
Neonatal and Maternal Infections
Type
article
Field-Weighted Citation Impact
0.00
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article

Management of the newborn at risk for vertical sepsis

Z. Galve Pradel, Concepción de Alba Romero, Fátima Camba Longueira, María González López et al.
Anales de Pediatría (English Edition)
Neonatal and Maternal Infections
article

Management of the newborn at risk for vertical sepsis

Z. Galve Pradel, Concepción de Alba Romero, Fátima Camba Longueira, María González López, María Cernada, Laura Sánchez García, María Cruz López Herrera, Ana Alarcón Allén, Elena Zamora Flores, Belén Fernández Colomer
article en

Abstract

Suspected early-onset sepsis (EOS) is one of the most frequent diagnoses in neonatal units; however, infection is not confirmed in most cases, leading to the widespread overuse of empirical antibiotherapy. This document presents a diagnostic and therapeutic approach to EOS and proposes evidence-based recommendations, supported by national epidemiological data, for the management of neonates at risk of EOS according to gestational age and individual risk level, in order to promote rational use of antibiotics in the neonatal period.

Anales de Pediatría (English Edition)Vol. 104(2)
Hospital Sant Joan de Déu Barcelona (ES), Hospital Universitario La Paz (ES), Hospital General Universitario Gregorio Marañón (ES), Hospital Universitario 12 De Octubre (ES), Hospital Universitario Miguel Servet (ES), Vall d'Hebron Hospital Universitari (ES), Hospital Materno-Infantil (ES), Hospital Universitario Central de Asturias (ES), Hospital de Cruces (ES), Instituto de Investigación Sanitaria La Fe (ES)
Good health and well-being
Openalex Percentile: Top 57%
Neonatal and Maternal Infections
DOIOpen Access PDFOpenAlex
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