Association between end-tidal sevoflurane concentration and postoperative cognitive dysfunction and pain sensitivity in elderly patients under general anesthesia
Higher end-tidal sevoflurane concentration is associated with improved postoperative cognitive function and reduced pain sensitivity in elderly patients, likely mediated by the modulation of neurological and pain-related biomarkers, serving as a protective factor against POCD.
Authors
- Zhengyu Li (ORCID: https://orcid.org/0000-0002-6102-0991)
- Hong Luo (ORCID: https://orcid.org/0000-0002-0592-5745)
- Zheng Han (ORCID: https://orcid.org/0000-0002-2367-2454)
- Yi-Xiang Wang (ORCID: https://orcid.org/0000-0002-4021-4228)
- Yunyun Zhou
- Lifen Zheng
- Xue Zhang
- Heng Yang
Institutions
- Zhejiang Chinese Medical University (CN)
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Third People's Hospital of Hefei (CN)
- Hefei First People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2026-02-16
- DOI
- https://doi.org/10.3389/fnagi.2026.1761052
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Anhui Medical University