Exploring the link between metabolic dysfunction-associated fatty liver disease and subclinical hypothyroidism in adolescents: a comprehensive review

In adolescents, MAFLD and SCH appear linked through metabolic and endocrine pathways, but causality remains unproven. Risk-based screening may be warranted-thyroid testing in MAFLD and targeted liver assessment in persistent SCH-while longitudinal cohorts and pediatric trials are needed to define thresholds for intervention and potential benefits of endocrine management.

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Publication Details

Journal
Frontiers in Pediatrics
Published
2026-02-16
DOI
https://doi.org/10.3389/fped.2026.1696331
Primary Topic
Liver Disease Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Exploring the link between metabolic dysfunction-associated fatty liver disease and subclinical hypothyroidism in adolescents: a comprehensive review

Guoshuai Xu, Wenqiang Li, Wenzai Shi, Nan Yao et al.
Frontiers in Pediatrics
Liver Disease Diagnosis and Treatment
article

Exploring the link between metabolic dysfunction-associated fatty liver disease and subclinical hypothyroidism in adolescents: a comprehensive review

Guoshuai Xu, Wenqiang Li, Wenzai Shi, Nan Yao, Guoyong Yu, Jun Qu, Xinlong Hu
article en

Abstract

In adolescents, MAFLD and SCH appear linked through metabolic and endocrine pathways, but causality remains unproven. Risk-based screening may be warranted-thyroid testing in MAFLD and targeted liver assessment in persistent SCH-while longitudinal cohorts and pediatric trials are needed to define thresholds for intervention and potential benefits of endocrine management.

Frontiers in PediatricsVol. 14
Peking University (CN), Aerospace Center Hospital (CN), Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN), Peking University International Hospital (CN)
Good health and well-being
Openalex Percentile: Top 54%
Liver Disease Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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Exploring the link between metabolic dysfunction-associated fatty liver disease and subclinical hypothyroidism in adolescents: a comprehensive review — Guoshuai Xu, Wenqiang Li, et al. · Frontiers in Pediatrics (2026) | TGRS Research Map | TGRS