Enhancing the interpretability of spinal cord atrophy in multiple sclerosis by reducing interindividual variability due to anatomical differences
eTIV, height and SCaA were valid normalisation factors of MUCCA. Multivariable normalisation (eTIV+SCaA) performed reduced anatomical dependency best but masked clinical-anatomical relations. Proportional normalisation using height allows for individual clinical assessment of spinal cord atrophy.
Authors
- Tom A. Fuchs (ORCID: https://orcid.org/0000-0002-0219-3518)
- Hugo Vrenken (ORCID: https://orcid.org/0000-0001-9106-1172)
- Joep Killestein (ORCID: https://orcid.org/0000-0002-6347-5957)
- Mar Barrantes-Cepas (ORCID: https://orcid.org/0009-0007-4305-6118)
- Eva M.M Strijbis
- Frederik Barkhof
- Daan J. de Jong
- Menno M. Schoonheim
- Samanta Noteboom
- Martijn D. Steenwijk
- Julia R. Jelgerhuis
Institutions
- Amsterdam Neuroscience (NL)
- University College London (GB)
- Vrije Universiteit Amsterdam (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Multiple Sclerosis and Related Disorders
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1016/j.msard.2026.107079
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00