Tocilizumab-loaded nanoparticles block IL-6R and reduce edema after intracerebral hemorrhage
Our findings demonstrate that PTPR NPs are an effective platform for targeted IL-6 receptor (IL-6R) blockade in ICH and suggest a potential for delivering biologics in other neuroinflammatory diseases.
Authors
- Leiyang Li
- Chengxuan Guo (ORCID: https://orcid.org/0009-0001-4353-8850)
- Shunnan Ge
- Jianyu Zhao (ORCID: https://orcid.org/0000-0001-9339-3533)
- Haixiao Liu (ORCID: https://orcid.org/0000-0002-3300-9576)
- Shuoyao Ma (ORCID: https://orcid.org/0009-0002-0058-9022)
- Yan Qu (ORCID: https://orcid.org/0000-0001-5434-7390)
- Fang Sun
- Liying Han
- Qian Lin
- Jinpeng Zhou
- Qiang Wang
- Yang Tian
- Wei Guo
- Jingyu Dong
- Jin Ma
- Dongzhi Xue
- Hao Guo
Institutions
- Tang Du Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.jare.2026.02.026
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00